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Research demonstrates up to 70% increases in type I collagen production in dermal fibroblasts at optimal concentrations

Copper supplementation in both animal models and humans (e.g., patients with SCO2 mutations) can restore CCO activity, reverse hypertrophy and fibrosis, and significantly improve cardiac function [51, 52]

The reduction in Se levels may also affect iodine utilization, further contributing to the enlargement of the thyroid gland and nodule formation [86]

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